Neuroendocrine Secretory Protein 55 (GNAS) Antibody

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This antibody is supplied as crude ascites.

Target	Neuroendocrine Secretory Protein 55 (GNAS)
Clonality	Monoclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/300. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 287-315 amino acids from human GNAS.
Isotype	IgM
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q5FWY2 (UniProt, ExPASy)
Molecular Weight	Calculated MW: 44.3 kDa
Buffer	Ascites containing 0.09% sodium azide.
Specificity	Predicted to react with Human, Rat, Cow, Pig and Hamster GNAS.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Neuroendocrine Secretory Protein 55 (GNAS)

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