Glucose 6 Phosphate Isomerase (GPI) Antibody

GPI belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

Target	Glucose 6 Phosphate Isomerase (GPI)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 445-473 amino acids from the C-terminal region of human GPI.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P06744 (UniProt, ExPASy)
UniProt Secondary AC	B4DG39, Q9BRD3, Q9BSK5, Q9UHE6
UniProt Entry Name	G6PI_HUMAN
KEGG	hsa:2821
String	9606.ENSP00000405573
Molecular Weight	Calculated MW: 63.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey GPI.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glucose 6 Phosphate Isomerase (GPI)

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