Glutamate Receptor 2 (GRIA2) Antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (Q/R and R/G), which is thought to render the channels impermeable to Ca (2+), and to affect the kinetic aspects of these channels in rat brain. Alternative splicing, resulting in transcript variants encoding different isoforms (flip and flop), has been noted for this gene.

Target	Glutamate Receptor 2 (GRIA2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human GRIA2 (AA: 652-807) expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P42262 (UniProt, ExPASy)
UniProt Secondary AC	A8MT92, I6L997, Q96FP6
UniProt Entry Name	GRIA2_HUMAN
Gene Symbol	GRIA2
GeneID	2891
OMIM	138247
HGNC	4572
KEGG	hsa:2891
Ensembl	ENSG00000120251
String	9606.ENSP00000296526
Molecular Weight	98.8 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Glutamate Receptor 2 (GRIA2)

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