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Gastrin Releasing Peptide Receptor (GRPR) Antibody
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Catalogue No: abx002146
Price:
US$203.00
(Size: 20 µl)
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GRPR Antibody is a Rabbit Polyclonal antibody against GRPR. Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Research Articles on Gastrin Releasing Peptide Receptor (GRPR)
| Target | Gastrin Releasing Peptide Receptor (GRPR) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P30550 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R910 |
| UniProt Entry Name | GRPR_HUMAN |
| Gene Symbol | GRPR |
| GeneID | 2925 |
| NCBI Accession | NP_005305.1 |
| KEGG | hsa:2925 |
| String | 9606.ENSP00000369643 |
| Molecular Weight | Calculated MW: 43 kDa Observed MW: 43 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |