GSK3 alpha Antibody

Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily.It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun.GSK3 phosphorylates glycogen synthase and thereby inactivates it.Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis.GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta.The two isoforms share 97% sequence similarity within their catalytic domains.GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Target	GSK3 alpha
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of GSK3 alpha expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49840 (UniProt, ExPASy)
UniProt Secondary AC	O14959
UniProt Entry Name	GSK3A_HUMAN
Gene Symbol	GSK3A
GeneID	2931
OMIM	606784
HGNC	4616
KEGG	hsa:2931
Ensembl	ENSG00000105723
String	9606.ENSP00000222330
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on GSK3 alpha

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