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Glutathione S Transferase Alpha 1 (GSTA1) Antibody
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Catalogue No: abx025297
Price:
US$601.75
(Size: 100 µl)
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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. This antibody is supplied as crude ascites.
Research Articles on Glutathione S Transferase Alpha 1 (GSTA1)
| Target | Glutathione S Transferase Alpha 1 (GSTA1) |
| Clonality | Monoclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB |
| Host | Mouse |
| Recommended dilutions | WB: 1/1000 - 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Human GSTA1 recombinant protein. |
| Isotype | IgM Kappa |
| Form | Liquid |
| Purification | Unpurified crude ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P08263 (UniProt, ExPASy) |
| UniProt Secondary AC | Q14750, Q5GHF8, Q5SZC1 |
| UniProt Entry Name | GSTA1_HUMAN |
| KEGG | hsa:2938 |
| String | 9606.ENSP00000335620 |
| Molecular Weight | Calculated MW: 25.6 kDa |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |