G/T Mismatch-Binding Protein (MSH6) Antibody

G/T Mismatch-Binding Protein (MSH6) Antibody is a Rabbit Polyclonal antibody for the detection of MSH6.

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Target	G/T Mismatch-Binding Protein (MSH6)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	mutS homolog 6
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P52701 (UniProt, ExPASy)
UniProt Secondary AC	B4DF41, B4E3I4, F5H2F9, O43706, O43917, Q8TCX4, Q9BTB5
UniProt Entry Name	MSH6_HUMAN
Gene Symbol	MSH6
GeneID	2956
OMIM	114500
HGNC	7329
KEGG	hsa:2956
Ensembl	ENSG00000116062
String	9606.ENSP00000234420
Molecular Weight	Observed MW: 120 kDa, 160 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on G/T Mismatch-Binding Protein (MSH6)

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