Guanine Nucleotide-Binding Protein Subunit Alpha-13 (GNA13) Antibody

Guanine Nucleotide-Binding Protein Subunit Alpha-13 (GNA13) Antibody is a Rabbit Polyclonal antibody for the detection of GNA13.

Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG. GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation.

Target	Guanine Nucleotide-Binding Protein Subunit Alpha-13 (GNA13)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	guanine nucleotide binding protein (G protein), alpha 13
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q14344 (UniProt, ExPASy)
UniProt Secondary AC	B2R977, B7Z7R0, F5H1G8, Q8TD70
UniProt Entry Name	GNA13_HUMAN
Gene Symbol	GNA13
GeneID	10672
OMIM	604406
HGNC	4381
KEGG	hsa:10672
Ensembl	ENSG00000120063
String	9606.ENSP00000400717
Molecular Weight	Observed MW: 44 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Guanine Nucleotide-Binding Protein Subunit Alpha-13 (GNA13)

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