Histone H2A.X (H2AFX) Antibody

REQUEST MORE INFO
Catalogue No: abx034795
Price: US$326.25
(Size: 50 µl)
Reviews: 0 Publications and Reviews
(0 Publications and Reviews)

Click on the image to see the image legend

Histone H2A.X (H2AFX) Antibody
Histone H2A.X (H2AFX) Antibody

Available Options

* Size:


Add to Shopping Cart Buy It Now GET A QUOTE

Documents

Datasheet SDS
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Target Histone H2A.X (H2AFX)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, WB, IHC
Host Mouse
Recommended dilutions WB: 1/1000, IHC-P: 1/25 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 115-143 amino acids from the C-terminal region of human H2AFX.
Isotype IgG1
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P16104 (UniProt, ExPASy)
UniProt Secondary AC Q4ZGJ7, Q6IAS5
UniProt Entry Name H2AX_HUMAN
NCBI Accession NP_002096.1
KEGG hsa:3014
String 9606.ENSP00000434024
Molecular Weight Calculated MW: 15.1 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Histone H2A.X (H2AFX)
Tags:
(Click to show)