Trifunctional Enzyme Subunit Beta, Mitochondrial (HADHB) Antibody

HADHB Antibody is a Rabbit Polyclonal antibody against HADHB. This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described.

Target	Trifunctional Enzyme Subunit Beta, Mitochondrial (HADHB)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 34-270 of human HADHB.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P55084 (UniProt, ExPASy)
UniProt Secondary AC	B2RB16, B4E2W0, O14969, Q53TA6, Q96C77, Q9H3F5, Q9T2V8
UniProt Entry Name	ECHB_HUMAN
Gene Symbol	HADHB
GeneID	3032
NCBI Accession	NP_000174.1
KEGG	hsa:3032
String	9606.ENSP00000325136
Molecular Weight	Calculated MW: 51 kDa Observed MW: 51 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Trifunctional Enzyme Subunit Beta, Mitochondrial (HADHB)

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