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Histone Deacetylase 11 (HDAC11) Antibody
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Catalogue No: abx026098
Price:
US$326.25
(Size: 80 µl)
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HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
Research Articles on Histone Deacetylase 11 (HDAC11)
| Target | Histone Deacetylase 11 (HDAC11) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 313-345 amino acids from the C-terminal region of human HDAC11. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q96DB2 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DDK1, Q9H6I7, Q9H6X3, Q9NTC9 |
| UniProt Entry Name | HDA11_HUMAN |
| NCBI Accession | NP_001129513.1 NP_079103.2 |
| KEGG | hsa:79885 |
| String | 9606.ENSP00000295757 |
| Molecular Weight | Calculated MW: 39.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |