Histone Deacetylase 4 (HDAC4) Antibody

HDAC4 Antibody is a Rabbit Polyclonal antibody against HDAC4. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Target	Histone Deacetylase 4 (HDAC4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 530-630 of human HDAC4.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P56524 (UniProt, ExPASy)
UniProt Secondary AC	E9PGB9, F5GX36, Q86YH7, Q9UND6
UniProt Entry Name	HDAC4_HUMAN
Gene Symbol	HDAC4
GeneID	9759
NCBI Accession	NP_006028.2
KEGG	hsa:9759
String	9606.ENSP00000264606
Molecular Weight	Calculated MW: 119 kDa Observed MW: 140 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Histone Deacetylase 4 (HDAC4)

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