HER4 (pY1284) Antibody

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Catalogue No: abx000119
Price: US$232.00
(Size: 20 µl)
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Western blot analysis of lysates from MCF7 cells using Phospho-ErbB4/HER4-Y1284 Antibody at 1/700 dilution. MCF7 cells were treated by IGF (200 ng/ml) at 37 °C for 30 minutes after serum-starvation overnight. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1/10000 dilution. Lysates/proteins: 20 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 30s.
HER4 (pY1284) Antibody

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Datasheet SDS
HER4 (pY1284) Antibody is a Rabbit Polyclonal antibody against HER4 (pY1284). This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Target HER4 (pY1284)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic phosphorylated peptide around Y1284 of human ErbB4/HER4.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15303 (UniProt, ExPASy)
UniProt Secondary AC B7ZLD7, B7ZLE2, B7ZLE3, Q2M1W1, Q59EW4
UniProt Entry Name ERBB4_HUMAN
Gene Symbol ERBB4
GeneID 2066
NCBI Accession NP_005226.1
KEGG hsa:2066
String 9606.ENSP00000342235
Molecular Weight Calculated MW: 147 kDa
Observed MW: 180 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on HER4 (pY1284)


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