Histone Cell Cycle Regulator (HIRA) Antibody

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Target	Histone Cell Cycle Regulator (HIRA)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human HIRA.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P54198 (UniProt, ExPASy)
UniProt Secondary AC	Q05BU9, Q8IXN2
UniProt Entry Name	HIRA_HUMAN
KEGG	hsa:7290
String	9606.ENSP00000263208
Molecular Weight	Calculated MW: 112 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse HIRA.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Histone Cell Cycle Regulator (HIRA)

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