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Histone Cell Cycle Regulator (HIRA) Antibody
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Catalogue No: abx032771
Price:
US$326.25
(Size: 80 µl)
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HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Research Articles on Histone Cell Cycle Regulator (HIRA)
| Target | Histone Cell Cycle Regulator (HIRA) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 431-461 amino acids from the Central region of human HIRA. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P54198 (UniProt, ExPASy) |
| UniProt Secondary AC | Q05BU9, Q8IXN2 |
| UniProt Entry Name | HIRA_HUMAN |
| NCBI Accession | NP_003316.3 |
| KEGG | hsa:7290 |
| String | 9606.ENSP00000263208 |
| Molecular Weight | Calculated MW: 112 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Chicken and Xenopus HIRA. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |