Histone Cluster 1, H2ab (HIST1H2AB) Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

Target	Histone Cluster 1, H2ab (HIST1H2AB)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human HIST1H2AB.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P04908 (UniProt, ExPASy)
UniProt Secondary AC	P28001, Q76P63
UniProt Entry Name	H2A1B_HUMAN
KEGG	hsa:3012 hsa:8335
String	9606.ENSP00000483842
Molecular Weight	Calculated MW: 14.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow, Monkey, Zebrafish and Xenopus H2AC4.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Histone Cluster 1, H2ab (HIST1H2AB)

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