Histone Deacetylase 4 (HDAC4) Antibody

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Target	Histone Deacetylase 4 (HDAC4)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human HDAC4 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P56524 (UniProt, ExPASy)
UniProt Secondary AC	E9PGB9, F5GX36, Q86YH7, Q9UND6
UniProt Entry Name	HDAC4_HUMAN
Gene Symbol	HDAC4
GeneID	9759
OMIM	600430
HGNC	14063
KEGG	hsa:9759
Ensembl	ENSG00000068024
String	9606.ENSP00000264606
Molecular Weight	119 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Histone Deacetylase 4 (HDAC4)

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