HLA class I histocompatibility antigen, B alpha chain (HLA-B) Antibody

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Target	HLA class I histocompatibility antigen, B alpha chain (HLA-B)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 62-90 amino acids from human HLA-B.
Isotype	IgM
Form	Liquid
Purification	Purified Mouse Monoclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01889 (UniProt, ExPASy)
UniProt Secondary AC	A0A2I6Q7B5, B0V0B8, G3GN01, O02862, O02956, O02957, O02960, O19555, O19556, O19595, O19615, O19624, O19625, O19627, O19641, O19651, O19675, O19692, O19758, O19779, O19783, O46702, O62897, O62901, O62915, O62917, O62919, O77933, O77959, O78053, O78138, O78160, O78163, O78172, O78173, O78180, O78217, O95730, O98140, P01890, P03989, P10317, P10318, P10319, P10320, P18463, P18464, P18465, P19373, P30460, P30461, P30462, P30463, P30464, P30465, P30466, P30467, P30468, P30469, P30470, P30471, P30472, P30473, P30474, P30475, P30476, P30477, P30478, P30479, P30480, P30481, P30482, P30483, P30484, P30485, P30486, P30487, P30488, P30489, P30490, P30491, P30492, P30493, P30494, P30495, P30496, P30497, P30498, P30513, P30685, P79489, P79490, P79496, P79504, P79523, P79524, P79542, P79555, Q04826, Q08136, Q29633, Q29636, Q29638, Q29661, Q29665, Q29678, Q29679, Q29681, Q29693, Q29695, Q29697, Q29718, Q29742, Q29749, Q29762, Q29764, Q29829, Q29836, Q29842, Q29845, Q29846, Q29847, Q29848, Q29850, Q29851, Q29852, Q29854, Q29855, Q29857, Q29858, Q29861, Q29924, Q29925, Q29933, Q29935, Q29936, Q29940, Q29953, Q29961, Q29982, Q30173, Q30198, Q31603, Q31610, Q31612, Q31613, Q546L8, Q546M4, Q5JP37, Q5QT24, Q5RIP1, Q5SRJ2, Q5TK76, Q5TK77, Q860I4, Q861B5, Q8HWF0, Q8MGQ3, Q8MHN4, Q8SNC5, Q95343, Q95344, Q95365, Q95369, Q95392, Q95HA3, Q95HA8, Q95HM9, Q95IA6, Q95IB8, Q95IH5, Q95J00, Q96IT9, Q9BCM6, Q9BCM7, Q9BCM8, Q9BD06, Q9BD38, Q9BD43, Q9GIL3, Q9GIM3, Q9GIX1, Q9GIY5, Q9GIZ0, Q9GIZ9, Q9GJ00, Q9GJ17, Q9GJ20, Q9GJ23, Q9GJ31, Q9GJF0, Q9GJM7, Q9MX21, Q9MY37, Q9MY42, Q9MY43, Q9MY61, Q9MY75, Q9MY78, Q9MY79, Q9MY84, Q9MY92, Q9MY93, Q9MY94, Q9MYB8, Q9MYC3, Q9MYC7, Q9MYF4, Q9MYG1, Q9TP35, Q9TP36, Q9TP37, Q9TP95, Q9TPQ7, Q9TPQ9, Q9TPR2, Q9TPR4, Q9TPS6, Q9TPT2, Q9TPT4, Q9TPT6, Q9TPV2, Q9TQG1, Q9TQH3, Q9TQH6, Q9TQH7, Q9TQH8, Q9TQH9, Q9TQM2, Q9TQN4, Q9TQN6, Q9UQS8, Q9UQT0
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on HLA class I histocompatibility antigen, B alpha chain (HLA-B)

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