HLA class I histocompatibility antigen, C alpha chain (HLA-C) Antibody

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.

Target	HLA class I histocompatibility antigen, C alpha chain (HLA-C)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 66-93 amino acids from the Central region of human HLA-C.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10321 (UniProt, ExPASy)
UniProt Secondary AC	O02863, O02864, O02865, O02866, O02958, O19505, O19652, O19676, O62879, O62882, O62883, O62888, O78060, O78061, O78062, O78063, O78067, O78068, O78069, O78072, O78083, O78090, O78091, O78149, O78165, O78166, O78178, O78202, O78203, O78211, O78214, P04222, P30499, P30500, P30501, P30502, P30503, P30504, P30505, P30506, P30507, P30508, P30509, P30510, P79498, Q07000, Q29631, Q29641, Q29643, Q29652, Q29743, Q29768, Q29862, Q29864, Q29865, Q29867, Q29921, Q29959, Q29960, Q29963, Q29986, Q29989, Q29990, Q29991, Q29992, Q29993, Q30192, Q31605, Q31627, Q860R1, Q860R2, Q95463, Q95603, Q95604, Q99528, Q9BD28, Q9GIK4, Q9GIK8, Q9GJ33, Q9MY30, Q9MY31, Q9MY35, Q9MY49, Q9MY74, Q9MYI3, Q9TNN7, Q9TNZ8, Q9TPS4, Q9TPV8, Q9TPX2, Q9TQB4, Q9TQJ5, Q9TQP9, Q9UM32, Q9UM33, Q9UM42, Q9UQS9
Molecular Weight	Calculated MW: 40.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on HLA class I histocompatibility antigen, C alpha chain (HLA-C)

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