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HLA Class II Histocompatibility Antigen, DM Beta Chain (HLA-DMB) Antibody
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Catalogue No: abx028893
Price:
US$326.25
(Size: 80 µl)
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HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Research Articles on HLA Class II Histocompatibility Antigen, DM Beta Chain (HLA-DMB)
| Target | HLA Class II Histocompatibility Antigen, DM Beta Chain (HLA-DMB) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 104-133 amino acids from the Central region of human HLA-DMB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P28068 (UniProt, ExPASy) |
| UniProt Secondary AC | O77936, Q13012, Q29751, Q58ZE2, Q5SNZ8, Q5STC4, Q9XRX2 |
| UniProt Entry Name | DMB_HUMAN |
| Gene Symbol | HLA-DMB |
| KEGG | hsa:3109 |
| String | 9606.ENSP00000398890 |
| Molecular Weight | Calculated MW: 28.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |