High Mobility Group Protein B2 (HMGB2) Antibody

HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V (D) J recombination.

Target	High Mobility Group Protein B2 (HMGB2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 92-118 amino acids from the Central region of human HMGB2.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P26583 (UniProt, ExPASy)
UniProt Secondary AC	B2R4K8, D3DP37, Q5U072
UniProt Entry Name	HMGB2_HUMAN
NCBI Accession	NP_001124160.1 NP_001124161.1 NP_002120.1
KEGG	hsa:3148
String	9606.ENSP00000296503
Molecular Weight	Calculated MW: 24 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat, Cow and Pig HMGB2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on High Mobility Group Protein B2 (HMGB2)

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