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Hypoxanthine-Guanine Phosphoribosyltransferase (HPRT) Antibody
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Catalogue No: abx011659
Price:
US$420.50
(Size: 100 µl)
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The HPRT1 gene provides instructions for making an enzyme called hypoxanthine phosphoribosyltransferase 1. This enzyme allows cells to recycle purines, some of the building blocks of DNA and its chemical cousin RNA.The enzyme hypoxanthine-guanine phosphoribosyltrasferase (E.C.2.4.2.8., HPRT) plays a crucial role in uric acid synthesis and purine metabolism.This enzyme catalyzes the conversion of hypoxanthine and guanine to inosine monophosphate (IMP) and guanosine monophosphate (GMP), respectively, and uses phosphoribosylpyrophosphate (PRPP) as a cosubstrate and as a source of energy. This pathway is also known as the purine salvage pathway because it allows cells to reuse purine compounds to build DNA and RNA.
Research Articles on Hypoxanthine-Guanine Phosphoribosyltransferase (HPRT)
| Target | Hypoxanthine-Guanine Phosphoribosyltransferase (HPRT) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of HPRT expressed in E. coli. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P00492 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NHF0, B2R8M9 |
| UniProt Entry Name | HPRT_HUMAN |
| Gene Symbol | HPRT1 |
| GeneID | 3251 |
| OMIM | 300322 |
| HGNC | 5157 |
| KEGG | hsa:3251 |
| Ensembl | ENSG00000165704 |
| String | 9606.ENSP00000298556 |
| Enzyme Commission Number | EC.2.4.2.8. |
| Molecular Weight | 25 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |