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GTPase HRas (HRAS) Antibody
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Catalogue No: abx026379
Price:
US$326.25
(Size: 80 µl)
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This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
Research Articles on GTPase HRas (HRAS)
| Target | GTPase HRas (HRAS) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 146-176 amino acids from the C-terminal region of human HRAS. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P01112 (UniProt, ExPASy) |
| UniProt Secondary AC | B5BUA0, Q14080, Q6FHV9, Q9BR65, Q9UCE2 |
| UniProt Entry Name | RASH_HUMAN |
| Gene Symbol | HRAS |
| GeneID | 3265 |
| OMIM | 109800 |
| KEGG | hsa:3265 |
| Ensembl | ENSG00000174775 |
| String | 9606.ENSP00000407586 |
| Molecular Weight | Calculated MW: 21.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat and Chicken HRAS. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |