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Endoplasmic Reticulum Chaperone BiP (HSPA5) Antibody
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Catalogue No: abx032389
Price:
US$326.25
(Size: 80 µl)
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When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.
Research Articles on Endoplasmic Reticulum Chaperone BiP (HSPA5)
| Target | Endoplasmic Reticulum Chaperone BiP (HSPA5) |
| Clonality | Polyclonal |
| Reactivity | Human, Zebrafish |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 261-289 amino acids from the Central region of human HSPA5. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P11021 (UniProt, ExPASy) |
| UniProt Secondary AC | B0QZ61, Q2EF78, Q9NPF1, Q9UK02 |
| UniProt Entry Name | BIP_HUMAN |
| KEGG | hsa:3309 |
| String | 9606.ENSP00000324173 |
| Molecular Weight | Calculated MW: 72.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow, Chicken and Hamster HSPA5. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |