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5-Hydroxytryptamine Receptor 2C (HTR2C) Antibody
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Catalogue No: abx027675
Price:
US$290.00
(Size: 80 µl)
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Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims.
Research Articles on 5-Hydroxytryptamine Receptor 2C (HTR2C)
| Target | 5-Hydroxytryptamine Receptor 2C (HTR2C) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 253-282 amino acids from the Central region of human HTR2C. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P28335 (UniProt, ExPASy) |
| UniProt Secondary AC | B1AMW4, Q5VUF8, Q9NP28 |
| UniProt Entry Name | 5HT2C_HUMAN |
| Gene Symbol | HTR2C |
| KEGG | hsa:3358 |
| String | 9606.ENSP00000276198 |
| Molecular Weight | Calculated MW: 51.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |