Serine Protease HTRA2, Mitochondrial (HTRA2) Antibody

HTRA2 Antibody is a Rabbit Polyclonal antibody against HTRA2. This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.

Target	Serine Protease HTRA2, Mitochondrial (HTRA2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 334-458 of human HTRA2.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O43464 (UniProt, ExPASy)
UniProt Secondary AC	Q9HBZ4, Q9P0Y3, Q9P0Y4
Gene Symbol	HTRA2
GeneID	27429
NCBI Accession	NP_037379.1
Molecular Weight	Calculated MW: 49 kDa Observed MW: 37 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serine Protease HTRA2, Mitochondrial (HTRA2)

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