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Human Aquaporin 2 (AQP2) CLIA Kit
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Catalogue No: abx491706
Price:
US$942.50
(Size: 96 tests)
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Human Aquaporin 2 (AQP2) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, urine and other biological fluids.
Research Articles on Aquaporin 2 (AQP2)
| Introduction | Aquaporin 2 (AQP2) is a protein found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell. It is the only aquaporin regulated by vasopressin. The basic job of aquaporin 2 is to reabsorb water from the urine while its being removed from the blood by the kidney. Aquaporin 2 is in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed, vasopressin binds to the cell surface vasopressin receptor thereby activating a signaling pathway that causes the aquaporin 2 containing vesicles to fuse with the plasma membrane, so the aquaporin 2 can be used by the cell. Mutations in this channel are associated with nephrogenic diabetes insipidus, which can be autosomal dominant or recessive. The expression of the AQP2 gene is increased during conditions associated with water retention such as pregnancy and congestive heart failure. |
| Target | Aquaporin 2 (AQP2) |
| Reactivity | Human |
| Tested Applications | CLIA |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Validity | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Stability | The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
| UniProt Primary AC | P41181 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9UD68 |
| UniProt Entry Name | AQP2_HUMAN |
| Gene Symbol | AQP2 |
| GeneID | 359 |
| OMIM | 107777 |
| HGNC | 634 |
| KEGG | hsa:359 |
| Ensembl | ENSG00000167580 |
| String | 9606.ENSP00000199280 |
| Test Range | 27.4 pg/ml - 20000 pg/ml |
| Sensitivity | < 9.3 pg/ml |
| Standard Form | Lyophilized |
| Detection Method | Chemiluminescent |
| Assay Type | Sandwich |
| Assay Data | Quantitative |
| Sample Type | Tissue homogenates, cell lysates, urine and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
| Standard | 20000 pg/ml |
