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Introduction | Aquaporin-4, also known as AQP4, is a water channel protein encoded by the AQP4 gene in humans. Aquaporin-4’s overall function is to provide fast water transportation as well as maintain homeostatic balance within the central nervous system. It is the primary water channel protein that reconciles the homeostasis of water in the CNS. AQP4 may be involved in a variety of physiological processes such as waste removal and fine-tuning of potassium homeostasis. Water flowing into and out of the brain or spinal cord is assisted by AQP4. Here, AQP4 channels respond passively to osmotic gradients. In addition, they play a role in brain water transport, cell migration, brain edema, metabolism and cell homeostasis. |
Target | Aquaporin 4 (AQP4) |
Reactivity | Human |
Tested Applications | ELISA |
Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
Validity | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
Stability | The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
UniProt Primary AC | P55087 (UniProt, ExPASy) |
UniProt Secondary AC | P78564 |
UniProt Entry Name | AQP4_HUMAN |
Gene Symbol | AQP4 |
GeneID | 361 |
OMIM | 600308 |
HGNC | 637 |
KEGG | hsa:361 |
Ensembl | ENSG00000171885 |
String | 9606.ENSP00000372654 |
Test Range | 0.625 ng/ml - 40 ng/ml |
Sensitivity | < 0.245 ng/ml |
Standard Form | Lyophilized |
Detection Method | Colorimetric |
Assay Type | Sandwich |
Assay Data | Quantitative |
Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
Availability | Shipped within 5-12 working days. |
Note | This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Standard | 40 ng/ml |