+44 (0) 1223 755950
+1 832 327 7413
Human Copeptin (CPP) ELISA Kit
REQUEST MORE INFO
Catalogue No: abx574597
Price:
US$797.50
(Size: 96 tests)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Add to Shopping Cart
Buy It Now
GET A QUOTE
Human Copeptin (CPP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Copeptin (CPP) concentrations in serum, plasma, tissue homogenates and other biological fluids.
Research Articles on Copeptin (CPP)
| Introduction | Copeptin (also known as CT-proAVP) is a 39-amino acid-long peptide derived from a pre-pro-hormone consisting of vasopressin, neurophysin II and copeptin. Arginine vasopressin (AVP), also known as the antidiuretic hormone (ADH), is involved in multiple cardiovascular and renal pathways and functions. However, vasopressin measurements are not commonly used in clinical practice because of the biochemical features of the molecule: its small size and very short half-life make vasopressin testing quite complicated and labor-intensive. On the other hand, copeptin can be immunologically tested with ease and therefore be used as a vasopressin surrogate. Copeptin is a 39-amino acid-long, glycosylated peptide. It is synthesized mainly in the paraventricular neurons of the hypothalamus and in the supraoptical nucleus. During axonal transport, pre-pro-AVP is proteolytically cleaved into vasopressin, neurophysin II and copeptin. These molecules are then stored in secretory granules in the posterior pituitary and released upon osmotic or non-osmotic (hemodynamical; stress-related) stimuli. Once secreted into the bloodstream, there is no known biological role for copeptin. However, when pre-pro-vasopressin is processed during the axonal transport, copeptin may contribute to the 3D folding of vasopressin. |
| Target | Copeptin (CPP) |
| Reactivity | Human |
| Tested Applications | ELISA |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Validity | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Stability | The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
| UniProt Primary AC | P01185 (UniProt, ExPASy) |
| UniProt Secondary AC | A0AV35, O14935 |
| UniProt Entry Name | NEU2_HUMAN |
| Gene Symbol | AVP |
| GeneID | 551 |
| OMIM | 125700 |
| KEGG | hsa:551 |
| String | 9606.ENSP00000369647 |
| Test Range | 7.8 pg/ml - 500 pg/ml |
| Sensitivity | < 3 pg/ml |
| Standard Form | Lyophilized |
| Detection Method | Colorimetric |
| Assay Type | Competitive |
| Assay Data | Quantitative |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
| Standard | 4000 pg/ml |