Human Immunodeficiency Virus 1 Surface Protein gp120 (HIV-1 gp120) Antibody

Human Immunodeficiency Virus 1 Surface Protein gp120 (HIV-1 gp120) Antibody (Group M, Subtype CRF07_BC) is a Mouse Monoclonal antibody for the detection of Human Immunodeficiency Virus 1 Surface Protein gp120 (HIV-1 gp120).

The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, which is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp12 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS.

Target	Human Immunodeficiency Virus 1 Surface Protein gp120 (HIV-1 gp120)
Clonality	Monoclonal
Reactivity	Virus
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/1000 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant HIV-1 gp120 Protein (group M, subtype CRF07_BC)
Isotype	IgG2b
Form	Liquid
Purification	Purified by Protein A affinity chromatography. 0.2 µm filtered.
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Buffer	PBS.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.
Directions for use	Centrifuge before opening to ensure complete recovery of vial contents.

Research Articles on Human Immunodeficiency Virus 1 Surface Protein gp120 (HIV-1 gp120)

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