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Human Liver Expressed Antimicrobial Peptide 2 (LEAP2) ELISA Kit
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Catalogue No: abx555914
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US$797.50
(Size: 96 tests)
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Human Liver Expressed Antimicrobial Peptide 2 (LEAP2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Liver-expressed antimicrobial peptide 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Research Articles on Liver Expressed Antimicrobial Peptide 2 (LEAP2)
| Introduction | Liver-expressed antimicrobial peptides are a family of mammalian liver-expressed antimicrobial peptides (LEAP). The exact function of this family is unclear. LEAP2 is a cysteine-rich, and cationic protein. LEAP2 contains a core structure with two disulphide bonds formed by cysteine residues in relative 1-3 and 2-4 positions. LEAP2 is synthesised as a 77-residue precursor, which is predominantly expressed in the liver and highly conserved among mammals. The largest native LEAP2 form of 40 amino acid residues is generated from the precursor at a putative cleavage site for a furin-like endoprotease. In contrast to smaller LEAP-2 variants, this peptide exhibits dose-dependent antimicrobial activity against selected microbial model organisms. |
| Target | Liver Expressed Antimicrobial Peptide 2 (LEAP2) |
| Reactivity | Human |
| Tested Applications | ELISA |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Validity | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Stability | The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
| UniProt Primary AC | Q969E1 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DQ91 |
| UniProt Entry Name | LEAP2_HUMAN |
| Gene Symbol | LEAP2 |
| KEGG | hsa:116842 |
| String | 9606.ENSP00000296877 |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.05 ng/ml |
| Detection Method | Colorimetric |
| Assay Type | Sandwich |
| Assay Data | Quantitative |
| Sample Type | issue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
| Standard | 50 ng/ml |
| Intra Assay | CV ≤ 7.1% |
| Inter Assay | CV ≤ 9.5% |