Human N6-Adenosine-Methyltransferase Catalytic Subunit (METTL3) ELISA Kit

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Catalogue No: abx381419
Price: US$797.50
(Size: 96 tests)
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Graph showing standard OD data for Human N6-Adenosine-Methyltransferase Catalytic Subunit (METTL3)
Human N6-Adenosine-Methyltransferase Catalytic Subunit (METTL3) ELISA Kit

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Datasheet SDS Download Manual
Human N6-Adenosine-Methyltransferase Catalytic Subunit (METTL3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human METTL3 concentrations in tissue homogenates, cell lysates and other biological fluids.

Introduction Methyltransferase Like Protein 3 (METTL3, also known as N6-adenosine-methyltransferase catalytic subunit) is a protein that forms a heterodimer with METTL14 in the nucleus. It catalyses the transfer of the methyl group on the sulphur atom of s-adenosyl methionine to adenosine in mRNA and microRNAs, creating an N6-methyladenosine residue and s-adenosyl homocysteine. METTL3/14 is involved in a wide variety of cellular processes, including circadian rhythm and differentiation. Zebrafish with mutations in METTL3 were less fertile due to dysregulated gamete formation.
Target N6-adenosine-methyltransferase 70 kDa subunit
Reactivity Human
Tested Applications ELISA
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Storage Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Validity The validity for this kit is 6 months.
Stability The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.
UniProt Primary AC Q86U44 (UniProt, ExPASy)
UniProt Secondary AC O14736, Q86V05, Q9HB32
UniProt Entry Name MTA70_HUMAN
Gene Symbol METTL3
OMIM 612472
HGNC 17563
KEGG hsa:56339
Ensembl ENSG00000165819
String 9606.ENSP00000298717
Test Range 0.312 ng/ml - 20 ng/ml
Sensitivity < 0.18 ng/ml
Standard Form Lyophilized
Detection Method Colorimetric
Assay Type Sandwich
Assay Data Quantitative
Sample Type Tissue homogenates, cell lysates and other biological fluids.
Availability Shipped within 5-15 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.

The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.

Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Standard 20 ng/ml
Research Articles on N6-adenosine-methyltransferase 70 kDa subunit
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