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Human N6-Adenosine-Methyltransferase Catalytic Subunit (METTL3) ELISA Kit
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Catalogue No: abx381419
Price:
US$797.50
(Size: 96 tests)
Orders to United States ship from United States
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Human N6-Adenosine-Methyltransferase Catalytic Subunit (METTL3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human METTL3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Research Articles on N6-adenosine-methyltransferase 70 kDa subunit
| Introduction | Methyltransferase Like Protein 3 (METTL3, also known as N6-adenosine-methyltransferase catalytic subunit) is a protein that forms a heterodimer with METTL14 in the nucleus. It catalyses the transfer of the methyl group on the sulphur atom of s-adenosyl methionine to adenosine in mRNA and microRNAs, creating an N6-methyladenosine residue and s-adenosyl homocysteine. METTL3/14 is involved in a wide variety of cellular processes, including circadian rhythm and differentiation. Zebrafish with mutations in METTL3 were less fertile due to dysregulated gamete formation. |
| Target | N6-adenosine-methyltransferase 70 kDa subunit |
| Reactivity | Human |
| Tested Applications | ELISA |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Validity | The validity for this kit is 6 months. |
| Stability | The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
| UniProt Primary AC | Q86U44 (UniProt, ExPASy) |
| UniProt Secondary AC | O14736, Q86V05, Q9HB32 |
| UniProt Entry Name | MTA70_HUMAN |
| Gene Symbol | METTL3 |
| OMIM | 612472 |
| HGNC | 17563 |
| KEGG | hsa:56339 |
| Ensembl | ENSG00000165819 |
| String | 9606.ENSP00000298717 |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.18 ng/ml |
| Standard Form | Lyophilized |
| Detection Method | Colorimetric |
| Assay Type | Sandwich |
| Assay Data | Quantitative |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
| Standard | 20 ng/ml |