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Human Superoxide Dismutase 1 (SOD1) Protein (Active)
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Catalogue No: abx060221
Price:
US$282.75
(Size: 100 µg)
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Human SOD Protein is a recombinant protein expressed in E. coli. Superoxide dismutases (SOD) are enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. Thus, they are an important antioxidant defense in nearly all cells exposed to oxygen. Several common forms of SOD exist: they are proteins cofactored with copper and zinc, or manganese, iron, or nickel. Thus, there are three major families of superoxide dismutase, depending on the metal cofactor: Cu/Zn (which binds both copper and zinc), Fe and Mn types (which bind either iron or manganese), and the Ni type, which binds nickel. Three forms of superoxide dismutase are present in humans, in all other mammals, and most chordates. SOD1 is located in the cytoplasm, SOD2 in the mitochondria, and SOD3 is extracellular. Mutations in the first SOD enzyme (SOD1) can cause familial amyotrophic lateral sclerosis (ALS, a form of motor neuron disease). The other two isoforms of SOD have not been linked to any human diseases, however, in mice inactivation of SOD2 causes perinatal lethality and inactivation of SOD1 causes hepatocellular carcinoma.
Research Articles on Superoxide Dismutase 1 (SOD1)
| Target | Superoxide Dismutase 1 (SOD1) |
| Origin | Human |
| Expression | Recombinant |
| Tested Applications | SDS-PAGE |
| Host | E. coli |
| Conjugation | Unconjugated |
| Form | Lyophilized |
| Purity | > 95% (HPLC and SDS-PAGE). Contains < 1% Dimers (SDS-PAGE) |
| Reconstitution | Reconstitute with sterile 18 MΩ-cm H2O. |
| Storage | Aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P00441 (UniProt, ExPASy) |
| UniProt Entry Name | SODC_HUMAN |
| GeneID | 6647 |
| OMIM | 147450 |
| KEGG | hsa:6647 |
| String | 9606.ENSP00000270142 |
| Molecular Weight | 16 kDa |
| Buffer | Prior to lyophilization: 10 mM Phosphate buffer and 200 mM NaCl (pH 7.0). Does not contain preservatives. |
| Activity | Active |
| Biological Activity | 8000 U/mg by Pyrogallic Acid method. |
| Endotoxin Level | < 0.1 ng/µg (1 EU/µg) by LAL test. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |