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Insulin Degrading Enzyme (IDE) Antibody
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Catalogue No: abx001373
Price:
US$232.00
(Size: 20 µl)
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IDE Antibody is a Rabbit Polyclonal antibody against IDE. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
Research Articles on Insulin Degrading Enzyme (IDE)
| Target | Insulin Degrading Enzyme (IDE) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human Insulin-degrading enzyme (IDE). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P14735 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R721, B7ZAU2, D3DR35, Q5T5N2 |
| UniProt Entry Name | IDE_HUMAN |
| Gene Symbol | IDE |
| GeneID | 3416 |
| NCBI Accession | NP_004960.2 |
| KEGG | hsa:3416 |
| String | 9606.ENSP00000265986 |
| Molecular Weight | Calculated MW: 118 kDa Observed MW: 118 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |