+44 (0) 1223 755950
+1 832 327 7413
Isocitrate Dehydrogenase 2, Mitochondrial (IDH2) Antibody
REQUEST MORE INFO
Catalogue No: abx005425
Price:
US$203.00
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
IDH2 Antibody is a Rabbit Polyclonal antibody against IDH2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants.
Research Articles on Isocitrate Dehydrogenase 2, Mitochondrial (IDH2)
| Target | Isocitrate Dehydrogenase 2, Mitochondrial (IDH2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/20 - 1/50, IP: 0.5-4 µg/200-400 µg whole cell extracts, ChIP: 5 µg/10-15 µg Chromatin. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 193-452 of human IDH2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P48735 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6L6, B4DFL2, Q96GT3 |
| UniProt Entry Name | IDHP_HUMAN |
| Gene Symbol | IDH2 |
| GeneID | 3418 |
| NCBI Accession | NP_002159.2 |
| KEGG | hsa:3418 |
| String | 9606.ENSP00000331897 |
| Molecular Weight | Calculated MW: 51 kDa Observed MW: 43 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |