Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody

IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines.Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs.The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation.Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation.Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151.Full kinase activation requires the triple tyrosine phosphorylation.

Target	Insulin Like Growth Factor 1 Receptor (IGF1R)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of IGF1R-Beta (AA: 1101-1367) expressed in E. coli.
Isotype	IgG2a
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08069 (UniProt, ExPASy)
UniProt Secondary AC	B1B5Y2, Q14CV2, Q9UCC0
UniProt Entry Name	IGF1R_HUMAN
Gene Symbol	IGF1R
GeneID	3480
OMIM	147370
HGNC	5465
KEGG	hsa:3480
Ensembl	ENSG00000140443
String	9606.ENSP00000268035
Molecular Weight	96 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Insulin Like Growth Factor 1 Receptor (IGF1R)

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