IKKB (pS672) Antibody

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Catalogue No: abx032160
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Target IKKB (pS672)
Clonality Polyclonal
Target Modification Ser672
Modification Phosphorylation
Reactivity Human
Tested Applications ELISA, DB
Host Rabbit
Recommended dilutions DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S672 of human IKKB.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O14920 (UniProt, ExPASy)
UniProt Secondary AC B4DZ30, B4E0U4, O75327
UniProt Entry Name IKKB_HUMAN
KEGG hsa:3551
String 9606.ENSP00000430684
Molecular Weight Calculated MW: 86.6 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse, Rat and Cow IKBKB.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on IKKB (pS672)


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