Interleukin 1 Beta (IL1B) Antibody

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq]. This antibody is supplied as crude ascites.

Target	Interleukin 1 Beta (IL1B)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/2000 - 1/4000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 148-174 amino acids from the Central region of human IL1B.
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P01584 (UniProt, ExPASy)
UniProt Secondary AC	Q53X59, Q53XX2, Q7M4S7, Q7RU01, Q96HE5, Q9UCT6
UniProt Entry Name	IL1B_HUMAN
KEGG	hsa:3553
String	9606.ENSP00000263341
Molecular Weight	Calculated MW: 30.7 kDa
Buffer	Ascites containing 0.09% sodium azide.
Specificity	Predicted to react with Monkey IL1B.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Interleukin 1 Beta (IL1B)

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