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Interleukin 6 Receptor (IL6R) Antibody
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Catalogue No: abx001321
Price:
US$203.00
(Size: 20 µl)
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IL6R Antibody is a Rabbit Polyclonal antibody against IL6R. Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL6R, the complex of IL-6 and IL6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL6R has been found in human serum and urine.
Research Articles on Interleukin 6 Receptor (IL6R)
| Target | Interleukin 6 Receptor (IL6R) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20-365 of human IL6R. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P08887 (UniProt, ExPASy) |
| UniProt Secondary AC | A8KAE8, B2R6V4, Q16202, Q53EQ7, Q5FWG2, Q5VZ23 |
| UniProt Entry Name | IL6RA_HUMAN |
| Gene Symbol | IL6R |
| GeneID | 3570 |
| NCBI Accession | NP_000556.1 |
| KEGG | hsa:3570 |
| String | 9606.ENSP00000357470 |
| Molecular Weight | Calculated MW: 52 kDa Observed MW: 70-100 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |