INSR (pY1185) Antibody

Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked.

Target	INSR (pY1185)
Clonality	Polyclonal
Target Modification	Tyr1185
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, DB
Host	Rabbit
Recommended dilutions	DB: 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P06213 (UniProt, ExPASy)
UniProt Secondary AC	Q17RW0, Q59H98, Q9UCB7, Q9UCB8, Q9UCB9
UniProt Entry Name	INSR_HUMAN
KEGG	hsa:3643
String	9606.ENSP00000303830
Molecular Weight	Calculated MW: 156 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow, Drosophila and Xenopus INSR.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on INSR (pY1185)

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