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Insulin Like Growth Factor 1 Receptor (IGF1R) Antibody
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Catalogue No: abx033572
Price:
US$326.25
(Size: 80 µl)
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The IGF1R receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.
Research Articles on Insulin Like Growth Factor 1 Receptor (IGF1R)
| Target | Insulin Like Growth Factor 1 Receptor (IGF1R) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/2000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 19-51 amino acids from the N-terminal region of human IGF1 Receptor (IGF1R). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P08069 (UniProt, ExPASy) |
| UniProt Secondary AC | B1B5Y2, Q14CV2, Q9UCC0 |
| UniProt Entry Name | IGF1R_HUMAN |
| NCBI Accession | NP_000866.1 |
| KEGG | hsa:3480 |
| String | 9606.ENSP00000268035 |
| Molecular Weight | Calculated MW: 155 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Rat IGF1R. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |