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Interleukin 1 Beta (IL1B) Antibody
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Catalogue No: abx239859
Price:
US$406.00
(Size: 100 µg)
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Interleukin 1 Beta (IL1B) Antibody is a Mouse Monoclonal antibody for the detection of IL1 Beta. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Research Articles on Interleukin 1 Beta (IL1B)
| Target | Interleukin 1 Beta (IL1B) |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Mouse |
| Recommended dilutions | WB: 1/1000 - 1/4000, IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | interleukin 1, beta |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P01584 (UniProt, ExPASy) |
| UniProt Secondary AC | Q53X59, Q53XX2, Q7M4S7, Q7RU01, Q96HE5, Q9UCT6 |
| UniProt Entry Name | IL1B_HUMAN |
| Gene Symbol | IL1B |
| GeneID | 3553 |
| OMIM | 147720 |
| HGNC | 5992 |
| KEGG | hsa:3553 |
| Ensembl | ENSG00000125538 |
| String | 9606.ENSP00000263341 |
| Molecular Weight | Observed MW: 35 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |