Importin 11 (IPO11) Antibody

IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).

Target	Importin 11 (IPO11)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human IPO11.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UI26 (UniProt, ExPASy)
UniProt Secondary AC	A6NGJ5, B4DZ73, D3DW98, Q8N5R2, Q9NSJ6, Q9NVB1
UniProt Entry Name	IPO11_HUMAN
Gene Symbol	IPO11
String	9606.ENSP00000386992
Molecular Weight	Calculated MW: 113 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse IPO11.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Importin 11 (IPO11)

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