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Iron-Responsive Element Binding Protein 2 (IREB2) Antibody
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Catalogue No: abx026945
Price:
US$290.00
(Size: 80 µl)
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IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Research Articles on Iron-Responsive Element Binding Protein 2 (IREB2)
| Target | Iron-Responsive Element Binding Protein 2 (IREB2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 201-230 amino acids from the Central region of human IREB2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P48200 (UniProt, ExPASy) |
| UniProt Entry Name | IREB2_HUMAN |
| KEGG | hsa:3658 |
| String | 9606.ENSP00000258886 |
| Molecular Weight | Calculated MW: 105 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat and Pig IREB2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |