Iron-Responsive Element Binding Protein 2 (IREB2) Antibody

IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

Target	Iron-Responsive Element Binding Protein 2 (IREB2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 201-230 amino acids from the Central region of human IREB2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48200 (UniProt, ExPASy)
UniProt Entry Name	IREB2_HUMAN
KEGG	hsa:3658
String	9606.ENSP00000258886
Molecular Weight	Calculated MW: 105 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Pig IREB2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Iron-Responsive Element Binding Protein 2 (IREB2)

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