Itchy E3 Ubiquitin Protein Ligase (ITCH) Antibody

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Catalogue No: abx027507
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

Target Itchy E3 Ubiquitin Protein Ligase (ITCH)
Clonality Polyclonal
Reactivity Mouse
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 509-536 amino acids from the Central region of human ITCH.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q96J02 (UniProt, ExPASy)
UniProt Entry Name ITCH_HUMAN
Gene Symbol ITCH
KEGG hsa:83737
String 9606.ENSP00000480499
Molecular Weight Calculated MW: 103 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Itchy E3 Ubiquitin Protein Ligase (ITCH)
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