+44 (0) 1223 755950
+1 832 327 7413
Integrin Alpha V (ITGAV) Antibody
REQUEST MORE INFO
Catalogue No: abx001703
Price:
US$203.00
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
ITGAV Antibody is a Rabbit Polyclonal antibody against ITGAV. This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes.
Research Articles on Integrin Alpha V (ITGAV)
| Target | Integrin Alpha V (ITGAV) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000 - 1/5000, IHC-P: 1/50 - 1/200, IP: 0.5-4 µg/200-400 µg whole cell extracts. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 950-1048 of human Integrin alpha V (ITGAV/CD51). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P06756 (UniProt, ExPASy) |
| UniProt Entry Name | ITAV_HUMAN |
| Gene Symbol | ITGAV |
| GeneID | 3685 |
| NCBI Accession | NP_002201.1 |
| KEGG | hsa:3685 |
| String | 9606.ENSP00000261023 |
| Molecular Weight | Calculated MW: 116 kDa Observed MW: 130 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |