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Integral Membrane Protein 2B (ITM2B) Antibody
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Catalogue No: abx027251
Price:
US$290.00
(Size: 80 µl)
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Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
Research Articles on Integral Membrane Protein 2B (ITM2B)
| Target | Integral Membrane Protein 2B (ITM2B) |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y287 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5W0A3, Q96B24, Q9NYH1 |
| UniProt Entry Name | ITM2B_HUMAN |
| Gene Symbol | ITM2B |
| String | 9606.ENSP00000367828 |
| Molecular Weight | Calculated MW: 30.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Monkey ITM2B. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |