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Tyrosine-protein kinase JAK1 (JAK1) Antibody
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Catalogue No: abx004237
Price:
US$203.00
(Size: 20 µl)
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Tyrosine-protein kinase JAK1 (JAK1) Antibody is a Rabbit Polyclonal antibody against Tyrosine-protein kinase JAK1 (JAK1). Tyrosine-protein kinase JAK1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
Research Articles on Tyrosine-protein kinase JAK1 (JAK1)
| Target | Tyrosine-protein kinase JAK1 (JAK1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 800-900 of human JAK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P23458 (UniProt, ExPASy) |
| UniProt Secondary AC | Q59GQ2, Q9UD26 |
| UniProt Entry Name | JAK1_HUMAN |
| Gene Symbol | JAK1 |
| GeneID | 3716 |
| NCBI Accession | NP_002218.2 |
| KEGG | hsa:3716 |
| String | 9606.ENSP00000343204 |
| Molecular Weight | Calculated MW: 133 kDa Observed MW: 133 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |