Jumonji/ARID Domain-Containing Protein 1B (JARID1B) Antibody

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.

Target	Jumonji/ARID Domain-Containing Protein 1B (JARID1B)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 192-224 amino acids from the N-terminal region of human JARID1B.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9UGL1 (UniProt, ExPASy)
UniProt Secondary AC	O95811, Q15752, Q9Y3Q5
UniProt Entry Name	KDM5B_HUMAN
Gene Symbol	KDM5B
String	9606.ENSP00000356234
Molecular Weight	Calculated MW: 176 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Jumonji/ARID Domain-Containing Protein 1B (JARID1B)

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