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JmjC Domain-Containing Histone Demethylation Protein 2A (JHDM2a) Antibody
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Catalogue No: abx026513
Price:
US$290.00
(Size: 80 µl)
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JHDM2a is a zinc finger protein that contains a jumonji domain. It is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. This protein preferentially demethylates mono and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. It is involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation.
Research Articles on JmjC Domain-Containing Histone Demethylation Protein 2A (JHDM2a)
| Target | JmjC Domain-Containing Histone Demethylation Protein 2A (JHDM2a) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human JHDM2a. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y4C1 (UniProt, ExPASy) |
| UniProt Secondary AC | D6W5M3, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08 |
| UniProt Entry Name | KDM3A_HUMAN |
| String | 9606.ENSP00000386660 |
| Molecular Weight | Calculated MW: 147 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |